NAD+ Therapy
A coenzyme central to cellular energy, infused slowly and dosed to where you are starting from.
What is NAD+ Therapy?
Nicotinamide adenine dinucleotide is infused intravenously at a deliberately slow rate for tolerability, or given as an intramuscular injection.
NAD+ is a coenzyme every cell uses in the reactions that convert nutrients into usable energy, and its availability declines with age. Supplementing it intravenously is used to support cellular energy, mental clarity and recovery. The practical point most clinics understate is that NAD+ must be infused slowly: given too quickly it produces chest tightness, cramping and nausea, so the rate is set for comfort and the appointments are long. A 500 mg infusion needs about three hours and 1,000 mg around five. Most patients start at 100 mg to see how they tolerate it, then move to 250 mg, which is the dose the standard five-session course is built on. An intramuscular injection is a faster way to trial NAD+ or to maintain between infusions, and 100 mg can be added to any other drip.
What is NAD and what does it do?
NAD — nicotinamide adenine dinucleotide — is a coenzyme present in every cell in the body, where it is essential to the reactions that convert what you eat into usable energy, and to a range of cellular repair and signalling processes. It is not an obscure supplement but a molecule cells cannot function without. Levels are understood to decline with age, and that observation is the basis on which NAD infusion is offered. It is worth being clear about the state of the evidence: the biochemistry is well established, while the clinical research on supplementing it intravenously in humans is still developing, and claims made about it in the wider market frequently run ahead of what has been demonstrated. A consultation should present it on that footing.
What does an NAD infusion feel like?
Distinctive, and worth knowing about in advance. NAD is characteristically infused slowly, and the reason is that running it quickly commonly produces chest tightness, flushing, nausea, abdominal cramping or a general sense of unease. These sensations are well recognised, are not dangerous in themselves, and resolve when the rate is reduced — which is exactly what the clinician monitoring you will do. Told about it beforehand, most people manage the infusion without difficulty; not told, it is alarming. Because of that pacing, an NAD appointment takes considerably longer than most other infusions, often several hours, and should be planned as an occupied afternoon rather than squeezed into a lunch break. Say something as soon as you feel uncomfortable rather than trying to tolerate it.
Who is NAD therapy for, and who should avoid it?
People generally seek it for fatigue that has not responded to the obvious measures, for mental clarity, or as part of a broader longevity-focused plan. Before pursuing it, the ordinary causes of fatigue deserve ruling out first — thyroid function, iron and B12 status, sleep quality, and medication effects among them — because treating tiredness with an infusion while an identifiable and correctable cause goes unexamined is the wrong order, and a good consultation will say so. It is avoided in pregnancy and breastfeeding, and requires review where there is significant cardiac, kidney or liver disease, or an active cancer. Current medications should be discussed. Anyone offering NAD as a cure for a defined medical condition is overstating what the evidence currently supports.
Medically reviewed by Dr. Sherwin Hariri, MD, Medical Director & Chief Longevity Physician. Last reviewed August 2026.
This page is for information only and is not medical advice. Suitability for any treatment is determined at consultation.
6 treatments in this category
NAD+ IV - 100 mg
Introductory NAD+ infusion for first-time patients, delivered slowly to minimize side effects.
NAD+ IV - 250 mg
Entry therapeutic dose of NAD+ supporting cellular energy, mental clarity and recovery.
NAD+ IV - 500 mg
Standard therapeutic NAD+ dose. Please allow three hours; the infusion is delivered slowly for comfort.
NAD+ IV - 1,000 mg
High-dose NAD+ for patients on an established protocol. A five-hour appointment; bring something to occupy you.
NAD+ IM Injection
Intramuscular NAD+ shot. A fast, lower-commitment way to trial NAD+ or to maintain between infusions.
NAD+ Course - 5 x 250 mg
A course of five 250 mg NAD+ infusions, the protocol most patients start on. Booked as five separate appointments.
Common questions
Why does an NAD+ infusion take so long?
Infused too quickly, NAD+ commonly causes chest tightness, cramping and nausea. The rate is set for your comfort, so a 500 mg infusion takes around three hours and 1,000 mg around five. Bring something to occupy you.
What dose should I start at?
Most first-time patients start at 100 mg to see how they tolerate it. The 250 mg dose is the usual therapeutic starting point and the one the five-session course is built on.
Is the injection as good as the infusion?
The intramuscular shot is a faster and lower-cost way to trial NAD+ or to maintain between infusions. It does not deliver what a full infusion does.
Not sure where to begin?
